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O(6)-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas
Temozolomide (TMZ) is an alkylating agent currently used as first-line therapy for gliomas treatment due to its DNA-damaging effect. However, drug resistance occurs, preventing multi-cycle use of this chemotherapeutic agent. One of the major mechanisms of cancer drug resistance is enhanced activity...
Enregistré dans:
| Publié dans: | Cell Death Dis |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4648381/ https://ncbi.nlm.nih.gov/pubmed/24157870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.388 |
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