O(6)-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas

Temozolomide (TMZ) is an alkylating agent currently used as first-line therapy for gliomas treatment due to its DNA-damaging effect. However, drug resistance occurs, preventing multi-cycle use of this chemotherapeutic agent. One of the major mechanisms of cancer drug resistance is enhanced activity...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Fan, C-H, Liu, W-L, Cao, H, Wen, C, Chen, L, Jiang, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648381/
https://ncbi.nlm.nih.gov/pubmed/24157870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.388
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