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ET-50 LEVETIRACETAM DOWNREGULATES O6-METHYLGUANINE DNA METHYLTRANSFERASE EXPRESSION AND SENSITIZES TEMOZOLOMIDE-RESISTANT GLIOMA CELLS
Temozolomide (TMZ) has become a key agent in treating malignant glioma; nevertheless, its survival benefit remains dismal prognosis. Histone deacetylases are often overexpressed in cancer cells, and this leads to altered expression and activity of numerous proteins involved in carcinogenesis. Recent...
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| Main Authors: | , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4218145/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.47 |
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