ET-50 LEVETIRACETAM DOWNREGULATES O6-METHYLGUANINE DNA METHYLTRANSFERASE EXPRESSION AND SENSITIZES TEMOZOLOMIDE-RESISTANT GLIOMA CELLS

Temozolomide (TMZ) has become a key agent in treating malignant glioma; nevertheless, its survival benefit remains dismal prognosis. Histone deacetylases are often overexpressed in cancer cells, and this leads to altered expression and activity of numerous proteins involved in carcinogenesis. Recent...

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Hauptverfasser: Saito, Norihiko, Aoki, Kazuya, Hirai, Nozomi, Ishii, Masashi, Tani, Mariko, Sato, Kenichiro, Nakayama, Haruo, Harashina, Junichi, Izukura, Hideaki, Ito, Keisuke, Sakurai, Takatoshi, Iwabuchi, Satoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218145/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou255.47
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