miR-29c contribute to glioma cells temozolomide sensitivity by targeting O(6)-methylguanine-DNA methyltransferases indirectly

Temozolomide (TMZ) is the most commonly used alkylating agent in glioma chemotherapy. However growing resistance to TMZ remains a major challenge to clinicians. The DNA repair protein O(6)-methylguanine-DNA methytransferase (MGMT) plays critical roles in TMZ resistance. Promoter methylation can inhi...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Xiao, Songhua, Yang, Zhen, Qiu, Xingsheng, Lv, Ruiyan, Liu, Jun, Wu, Ming, Liao, Yiwei, Liu, Qing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226579/
https://ncbi.nlm.nih.gov/pubmed/27384876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10357
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