Azole Affinity of Sterol 14α-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens

Tekijä Warrilow, Andrew G., Parker, Josie E., Kelly, Diane E., Kelly, Steven L.
Julkaistu 2013

Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14α-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoe...

Tekijä Martel, Claire M., Parker, Josie E., Warrilow, Andrew G. S., Rolley, Nicola J., Kelly, Steven L., Kelly, Diane E.
Julkaistu 2010

In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus

Tekijä Warrilow, Andrew G. S., Parker, Josie E., Price, Claire L., Nes, W. David, Kelly, Steven L., Kelly, Diane E.
Julkaisussa Antimicrob Agents Chemother (2015)

An Enlarged, Adaptable Active Site in CYP164 Family P450 Enzymes, the Sole P450 in Mycobacterium leprae

Tekijä Agnew, Christopher R. J., Warrilow, Andrew G. S., Burton, Nicholas M., Lamb, David C., Kelly, Steven L., Brady, R. Leo
Julkaistu 2012

Resistance to antifungals that target CYP51

Tekijä Parker, Josie E., Warrilow, Andrew G. S., Price, Claire L., Mullins, Jonathan G. L., Kelly, Diane E., Kelly, Steven L.
Julkaistu 2014

Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-α Demethylase (CYP51) Isoenzymes A and B

Tekijä Warrilow, Andrew G. S., Melo, Nadja, Martel, Claire M., Parker, Josie E., Nes, W. David, Kelly, Steven L., Kelly, Diane E.
Julkaistu 2010

Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases

Tekijä Hull, Claire M., Warrilow, Andrew G. S., Rolley, Nicola J., Price, Claire L., Donnison, Iain S., Kelly, Diane E., Kelly, Steven L.
Julkaisussa Biotechnol Biofuels (2017)

Identification, Characterization, and Azole-Binding Properties of Mycobacterium smegmatis CYP164A2, a Homolog of ML2088, the Sole Cytochrome P450 Gene of Mycobacterium leprae

Tekijä Warrilow, Andrew G. S., Jackson, Colin J., Parker, Josie E., Marczylo, Timothy H., Kelly, Diane E., Lamb, David C., Kelly, Steven L.
Julkaistu 2009

The First Virally Encoded Cytochrome P450

Tekijä Lamb, David C., Lei, Li, Warrilow, Andrew G. S., Lepesheva, Galina I., Mullins, Jonathan G. L., Waterman, Michael R., Kelly, Steven L.
Julkaistu 2009

A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14α-Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin B

Tekijä Martel, Claire M., Parker, Josie E., Bader, Oliver, Weig, Michael, Gross, Uwe, Warrilow, Andrew G. S., Kelly, Diane E., Kelly, Steven L.
Julkaistu 2010

Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Ampho...

Tekijä Hull, Claire M., Parker, Josie E., Bader, Oliver, Weig, Michael, Gross, Uwe, Warrilow, Andrew G. S., Kelly, Diane E., Kelly, Steven L.
Julkaistu 2012

Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations in ERG2

Tekijä Hull, Claire M., Bader, Oliver, Parker, Josie E., Weig, Michael, Gross, Uwe, Warrilow, Andrew G. S., Kelly, Diane E., Kelly, Steven L.
Julkaistu 2012

S279 Point Mutations in Candida albicans Sterol 14-α Demethylase (CYP51) Reduce In Vitro Inhibition by Fluconazole

Tekijä Warrilow, Andrew G. S., Mullins, Jonathan G. L., Hull, Claire M., Parker, Josie E., Lamb, David C., Kelly, Diane E., Kelly, Steven L.
Julkaistu 2012

Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase

Tekijä Price, Claire L., Warrilow, Andrew G. S., Parker, Josie E., Mullins, Jonathan G. L., Nes, W. David, Kelly, Diane E., Kelly, Steven L.
Julkaisussa Appl Environ Microbiol (2015)

Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans

Tekijä Martel, Claire M., Parker, Josie E., Bader, Oliver, Weig, Michael, Gross, Uwe, Warrilow, Andrew G. S., Rolley, Nicola, Kelly, Diane E., Kelly, Steven L.
Julkaistu 2010

Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51)

Tekijä Warrilow, Andrew G. S., Martel, Claire M., Parker, Josie E., Melo, Nadja, Lamb, David C., Nes, W. David, Kelly, Diane E., Kelly, Steven L.
Julkaistu 2010

The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions

Tekijä Warrilow, Andrew G., Nishimoto, Andrew T., Parker, Josie E., Price, Claire L., Flowers, Stephanie A., Kelly, Diane E., Rogers, P. David, Kelly, Steven L.
Julkaisussa Antimicrob Agents Chemother (2019)

Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14α-Demethylase (CYP51)

Tekijä Warrilow, Andrew G. S., Hull, Claire M., Rolley, Nicola J., Parker, Josie E., Nes, W. David, Smith, Stephen N., Kelly, Diane E., Kelly, Steven L.
Julkaistu 2014

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)

Tekijä Lamb, David C., Warrilow, Andrew G. S., Rolley, Nicola J., Parker, Josie E., Nes, W. David, Smith, Stephen N., Kelly, Diane E., Kelly, Steven L.
Julkaisussa Antimicrob Agents Chemother (2015)

Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans

Tekijä Binjubair, Faizah A., Parker, Josie E., Warrilow, Andrew G., Puri, Kalika, Braidley, Peter J., Tatar, Esra, Kelly, Steven L., Kelly, Diane E., Simons, Claire
Julkaisussa ChemMedChem (2020)