Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14α-Demethylase (CYP51)

A candidate CYP51 gene encoding sterol 14α-demethylase from the fish oomycete pathogen Saprolegnia parasitica (SpCYP51) was identified based on conserved CYP51 residues among CYPs in the genome. It was heterologously expressed in Escherichia coli, purified, and characterized. Lanosterol, eburicol, a...

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Detalhes bibliográficos
Main Authors: Warrilow, Andrew G. S., Hull, Claire M., Rolley, Nicola J., Parker, Josie E., Nes, W. David, Smith, Stephen N., Kelly, Diane E., Kelly, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Environmental Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178690/
https://ncbi.nlm.nih.gov/pubmed/25085484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01195-14
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