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Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51)
Purified Candida albicans sterol 14-α demethylase (CaCYP51) bound the CYP51 substrates lanosterol and eburicol, producing type I binding spectra with K(s) values of 11 and 25 μM, respectively, and a K(m) value of 6 μM for lanosterol. Azole binding to CaCYP51 was “tight” with both the type II spectra...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2944560/ https://ncbi.nlm.nih.gov/pubmed/20625155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00587-10 |
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