Azole Binding Properties of Candida albicans Sterol 14-α Demethylase (CaCYP51)

Purified Candida albicans sterol 14-α demethylase (CaCYP51) bound the CYP51 substrates lanosterol and eburicol, producing type I binding spectra with K(s) values of 11 and 25 μM, respectively, and a K(m) value of 6 μM for lanosterol. Azole binding to CaCYP51 was “tight” with both the type II spectra...

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Autores principales: Warrilow, Andrew G. S., Martel, Claire M., Parker, Josie E., Melo, Nadja, Lamb, David C., Nes, W. David, Kelly, Diane E., Kelly, Steven L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944560/
https://ncbi.nlm.nih.gov/pubmed/20625155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00587-10
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