The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions

Recombinant Candida albicans CYP51 (CaCYP51) proteins containing 23 single and 5 double amino acid substitutions found in clinical strains and the wild-type enzyme were expressed in Escherichia coli and purified by Ni(2+)-nitrilotriacetic acid agarose chromatography. Catalytic tolerance to azole ant...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Warrilow, Andrew G., Nishimoto, Andrew T., Parker, Josie E., Price, Claire L., Flowers, Stephanie A., Kelly, Diane E., Rogers, P. David, Kelly, Steven L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2019
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496074/
https://ncbi.nlm.nih.gov/pubmed/30783005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02586-18
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы