The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions

Recombinant Candida albicans CYP51 (CaCYP51) proteins containing 23 single and 5 double amino acid substitutions found in clinical strains and the wild-type enzyme were expressed in Escherichia coli and purified by Ni(2+)-nitrilotriacetic acid agarose chromatography. Catalytic tolerance to azole ant...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Warrilow, Andrew G., Nishimoto, Andrew T., Parker, Josie E., Price, Claire L., Flowers, Stephanie A., Kelly, Diane E., Rogers, P. David, Kelly, Steven L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496074/
https://ncbi.nlm.nih.gov/pubmed/30783005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02586-18
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