S279 Point Mutations in Candida albicans Sterol 14-α Demethylase (CYP51) Reduce In Vitro Inhibition by Fluconazole

The effects of S279F and S279Y point mutations in Candida albicans CYP51 (CaCYP51) on protein activity and on substrate (lanosterol) and azole antifungal binding were investigated. Both S279F and S279Y mutants bound lanosterol with 2-fold increased affinities (K(s), 7.1 and 8.0 μM, respectively) com...

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Main Authors: Warrilow, Andrew G. S., Mullins, Jonathan G. L., Hull, Claire M., Parker, Josie E., Lamb, David C., Kelly, Diane E., Kelly, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318376/
https://ncbi.nlm.nih.gov/pubmed/22252802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05389-11
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