S279 Point Mutations in Candida albicans Sterol 14-α Demethylase (CYP51) Reduce In Vitro Inhibition by Fluconazole

The effects of S279F and S279Y point mutations in Candida albicans CYP51 (CaCYP51) on protein activity and on substrate (lanosterol) and azole antifungal binding were investigated. Both S279F and S279Y mutants bound lanosterol with 2-fold increased affinities (K(s), 7.1 and 8.0 μM, respectively) com...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Warrilow, Andrew G. S., Mullins, Jonathan G. L., Hull, Claire M., Parker, Josie E., Lamb, David C., Kelly, Diane E., Kelly, Steven L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2012
Gaiak:
Mechanisms of Resistance
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318376/
https://ncbi.nlm.nih.gov/pubmed/22252802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05389-11
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