Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa

Malassezia globosa cytochromes P450 CYP51 and CYP5218 are sterol 14α-demethylase (the target of azole antifungals) and a putative fatty acid metabolism protein (and a potential azole drug target), respectively. Lanosterol, eburicol and obtusifoliol bound to CYP51 with K(d) values of 32, 23 and 28 μM...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Warrilow, Andrew G. S., Price, Claire L., Parker, Josie E., Rolley, Nicola J., Smyrniotis, Christopher J., Hughes, David D., Thoss, Vera, Nes, W. David, Kelly, Diane E., Holman, Theodore R., Kelly, Steven L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904373/
https://ncbi.nlm.nih.gov/pubmed/27291783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27690
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