Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)

In this study, we investigate the amebicidal activities of the pharmaceutical triazole CYP51 inhibitors fluconazole, itraconazole, and voriconazole against Acanthamoeba castellanii and Acanthamoeba polyphaga and assess their potential as therapeutic agents against Acanthamoeba infections in humans....

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Lamb, David C., Warrilow, Andrew G. S., Rolley, Nicola J., Parker, Josie E., Nes, W. David, Smith, Stephen N., Kelly, Diane E., Kelly, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505289/
https://ncbi.nlm.nih.gov/pubmed/26014948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00476-15
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