A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14α-Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin B

A clinical isolate of Candida albicans was identified as an erg5 (encoding sterol C22 desaturase) mutant in which ergosterol was not detectable and ergosta 5,7-dienol comprised >80% of the total sterol fraction. The mutant isolate (CA108) was resistant to fluconazole, voriconazole, itraconazole,...

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Bibliographic Details
Main Authors: Martel, Claire M., Parker, Josie E., Bader, Oliver, Weig, Michael, Gross, Uwe, Warrilow, Andrew G. S., Kelly, Diane E., Kelly, Steven L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934972/
https://ncbi.nlm.nih.gov/pubmed/20547793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00303-10
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