Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans

Sterol analysis identified four Candida albicans erg3 mutants in which ergosta 7,22-dienol, indicative of perturbations in sterol Δ(5,6)-desaturase (Erg3p) activity, comprised >5% of the total sterol fraction. The erg3 mutants (CA12, CA488, CA490, and CA1008) were all resistant to fluconazole, vo...

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Detalhes bibliográficos
Main Authors: Martel, Claire M., Parker, Josie E., Bader, Oliver, Weig, Michael, Gross, Uwe, Warrilow, Andrew G. S., Rolley, Nicola, Kelly, Diane E., Kelly, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976150/
https://ncbi.nlm.nih.gov/pubmed/20733039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00348-10
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