In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus

The incidence of triazole-resistant Aspergillus infections is increasing worldwide, often mediated through mutations in the CYP51A amino acid sequence. New classes of azole-based drugs are required to combat the increasing resistance to existing triazole therapeutics. In this study, a CYP51 reconsti...

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Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Warrilow, Andrew G. S., Parker, Josie E., Price, Claire L., Nes, W. David, Kelly, Steven L., Kelly, Diane E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2015
Onderwerpen:
Mechanisms of Resistance
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649140/
https://ncbi.nlm.nih.gov/pubmed/26459890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01806-15
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