MHC restriction is imposed on a diverse TCR repertoire by CD4 and CD8 coreceptors during thymic selection

af Van Laethem, François, Tikhonova, Anastasia N., Singer, Alfred
Udgivet 2012

Induction of autoimmune disease in CTLA-4(−/−) mice depends on a specific CD28 motif that is required for in vivo costimulation

af Tai, Xuguang, Van Laethem, Francois, Sharpe, Arlene H., Singer, Alfred
Udgivet 2007

Rôle crucial des corécepteurs CD4 et CD8 dans la reconnaissance antigénique des lymphocytes Tαβ

af Van Laethem, François, Saba, Ingrid, Tikhonova, Anastasia N., Singer, Alfred
Udgivet i Med Sci (Paris) (2014)

T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1

af Katz, Gil, Pobezinsky, Leonid A., Jeurling, Susanna, Shinzawa, Miho, Van Laethem, Francois, Singer, Alfred
Udgivet i Sci Signal (2014)

Upregulation of CD4 Expression during MHC-II Specific Positive Selection is Essential for Error-free Lineage Choice

af Sarafova, Sophia D., Van Laethem, Francois, Adoro, Stanley, Guinter, Terry, Sharrow, Susan O., Feigenbaum, Lionel, Singer, Alfred
Udgivet 2009

Targeting CD4 Coreceptor Expression to Postselection Thymocytes Reveals That CD4/CD8 Lineage Choice Is neither Error-Prone nor Stochastic

af Adoro, Stanley, Erman, Batu, Sarafova, Sophia D., Van Laethem, François, Park, Jung-Hyun, Feigenbaum, Lionel, Singer, Alfred
Udgivet i J Immunol (2008)

Glucocorticoids Attenuate T Cell Receptor Signaling

af Van Laethem, François, Baus, Erika, Smyth, Lesley A., Andris, Fabienne, Bex, Françoise, Urbain, Jacques, Kioussis, Dimitris, Leo, Oberdan
Udgivet 2001

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

af Pobezinsky, Leonid A., Angelov, Georgi S., Tai, Xuguang, Jeurling, Susanna, Van Laethem, François, Feigenbaum, Lionel, Park, Jung-Hyun, Singer, Alfred
Udgivet 2012

Structure of MHC-independent T cell receptors and their recognition of native antigen CD155

af Lu, Jinghua, Van Laethem, François, Saba, Ingrid, Chu, Jonathan, Tikhonova, Anastasia N., Bhattacharya, Abhisek, Singer, Alfred, Sun, Peter D.
Udgivet i J Immunol (2020)

TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells

af Takada, Kensuke, Van Laethem, Francois, Xing, Yan, Akane, Kazuyuki, Suzuki, Haruhiko, Murata, Shigeo, Tanaka, Keiji, Jameson, Stephen C., Singer, Alfred, Takahama, Yousuke
Udgivet i Nat Immunol (2015)

Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells

af Tai, Xuguang, Van Laethem, François, Pobezinsky, Leonid, Guinter, Terry, Sharrow, Susan O., Adams, Anthony, Granger, Larry, Kruhlak, Michael, Lindsten, Tullia, Thompson, Craig B., Feigenbaum, Lionel, Singer, Alfred
Udgivet 2012

Coreceptor gene imprinting governs thymocyte lineage fate

af Adoro, Stanley, McCaughtry, Thomas, Erman, Batu, Alag, Amala, Van Laethem, François, Park, Jung-Hyun, Tai, Xuguang, Kimura, Motoko, Wang, Lie, Grinberg, Alex, Kubo, Masato, Bosselut, Remy, Love, Paul, Singer, Alfred
Udgivet 2012

Lck availability during thymic selection determines the recognition specificity of the T cell repertoire

af Van Laethem, François, Tikhonova, Anastasia N., Pobezinsky, Leonid A., Tai, Xuguang, Kimura, Motoko Y., Le Saout, Cecile, Guinter, Terry I., Adams, Anthony, Sharrow, Susan O., Bernhardt, Günter, Feigenbaum, Lionel, Singer, Alfred
Udgivet 2013

Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus

af Van Laethem, François, Saba, Ingrid, Lu, Jinghua, Bhattacharya, Abhisek, Tai, Xuguang, Guinter, Terry I., Engelhardt, Britta, Alag, Amala, Rojano, Mirelle, Ashe, Jennifer M., Hanada, Ken-ichi, Yang, James C., Sun, Peter D., Singer, Alfred
Udgivet i Front Immunol (2020)

αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities

af Tikhonova, Anastasia N., Van Laethem, François, Hanada, Ken-ichi, Lu, Jinghua, Pobezinsky, Leonid A., Hong, Changwan, Guinter, Terry I., Jeurling, Susanna K., Bernhardt, Günter, Park, Jung-Hyun, Yang, James C., Sun, Peter D., Singer, Alfred
Udgivet 2011

Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire

af Lu, Jinghua, Van Laethem, François, Bhattacharya, Abhisek, Craveiro, Marco, Saba, Ingrid, Chu, Jonathan, Love, Nicholas C., Tikhonova, Anastasia, Radaev, Sergei, Sun, Xiaoping, Ko, Annette, Arnon, Tomer, Shifrut, Eric, Friedman, Nir, Weng, Nan-Ping, Singer, Alfred, Sun, Peter D.
Udgivet i Nat Commun (2019)

Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

af Harrison, Oliver J., Linehan, Jonathan L., Shih, Han-Yu, Bouladoux, Nicolas, Han, Seong-Ji, Smelkinson, Margery, Sen, Shurjo K., Byrd, Allyson L., Enamorado, Michel, Yao, Chen, Tamoutounour, Samira, Van Laethem, Francois, Hurabielle, Charlotte, Collins, Nicholas, Paun, Andrea, Salcedo, Rosalba, O’Shea, John J., Belkaid, Yasmine
Udgivet i Science (2018)