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MHC restriction is imposed on a diverse TCR repertoire by CD4 and CD8 coreceptors during thymic selection
Mature αβT cells recognize foreign antigenic peptides presented by MHC molecules but do not recognize native antigenic proteins , features known as MHC-restriction. How MHC-restriction is imposed on αβT cells has intrigued immunologists for decades. One model proposes that germline-encoded elements...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427466/ https://ncbi.nlm.nih.gov/pubmed/22771139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2012.05.006 |
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