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The Activation Threshold of CD4(+) T Cells Is Defined by TCR/Peptide-MHC Class II Interactions in the Thymic Medulla
Immature thymocytes that are positively selected based upon their response to self-peptide-MHC complexes develop into mature T cells that are not overtly reactive to those same complexes. Developmental tuning is the active process through which TCR-associated signaling pathways of single-positive th...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3079251/ https://ncbi.nlm.nih.gov/pubmed/19843939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901104 |
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