Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC

Recent work has demonstrated that nonstimulatory endogenous peptides can enhance T cell recognition of antigen, but MHCI- and MHCII-restricted systems have generated very different results. MHCII-restricted TCRs need to interact with the nonstimulatory peptide–MHC (pMHC), showing peptide specificity...

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Autors principals: Hoerter, John A.H., Brzostek, Joanna, Artyomov, Maxim N., Abel, Steven M., Casas, Javier, Rybakin, Vasily, Ampudia, Jeanette, Lotz, Carina, Connolly, Janet M., Chakraborty, Arup K., Gould, Keith G., Gascoigne, Nicholas R.J.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754861/
https://ncbi.nlm.nih.gov/pubmed/23940257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122528
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