Initiation of TCR Phosphorylation and Signal Transduction

Recent data with CD8+ T cells show that the initial phase of T cell receptor (TCR) binding to MHC–peptide (MHCp) is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data p...

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Bibliographic Details
Main Authors: Gascoigne, Nicholas R. J., Casas, Javier, Brzostek, Joanna, Rybakin, Vasily
Format: Artigo
Language:Inglês
Published: Frontiers Research Foundation 2011
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342367/
https://ncbi.nlm.nih.gov/pubmed/22566861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2011.00072
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