Expansion of an Unusual Virtual Memory CD8(+) Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice

Deletion of the gene for Themis affects T cell selection in the thymus, which would be expected to affect the TCR repertoire. We found an increased proportion of cells expressing Vα3.2 (TRAV9N-3) in the peripheral CD8(+) T cell population in mice with germline Themis deficiency. Analysis of the TCRα...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Prasad, Mukul, Wojciech, Lukasz, Brzostek, Joanna, Hu, Jianfang, Chua, Yen Leong, Tung, Desmond Wai Hon, Yap, Jiawei, Rybakin, Vasily, Gascoigne, Nicholas R. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058184/
https://ncbi.nlm.nih.gov/pubmed/33897691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.644483
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