Themis-associated phosphatase activity controls signaling in T cell development

Thymocyte-expressed molecule involved in selection (Themis) has been shown to be important for T cell selection by setting the threshold for positive versus negative selection. Themis interacts with the protein tyrosine phosphatase (PTP) Src-homology domain containing phosphatase-1 (Shp1), a negativ...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mehta, Monika, Brzostek, Joanna, Chen, Elijah W., Tung, Desmond W. H., Chen, Shuting, Sankaran, Shvetha, Yap, Jiawei, Rybakin, Vasily, Gascoigne, Nicholas R. J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275480/
https://ncbi.nlm.nih.gov/pubmed/30413615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720209115
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