A Dual Inhibitor of Cdc7/Cdk9 Potently Suppresses T Cell Activation

T cell activation is mediated by signaling pathways originating from the T cell receptor (TCR). Propagation of signals downstream of the TCR involves a cascade of numerous kinases, some of which have yet to be identified. Through a screening strategy that we have previously introduced, PHA-767491, a...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Chen, Elijah W., Tay, Neil Q., Brzostek, Joanna, Gascoigne, Nicholas R. J., Rybakin, Vasily
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670834/
https://ncbi.nlm.nih.gov/pubmed/31402912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01718
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