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Cdk1-mediated phosphorylation of Cdc7 suppresses DNA re-replication

To maintain genetic stability, the entire mammalian genome must replicate only once per cell cycle. This is largely achieved by strictly regulating the stepwise formation of the pre-replication complex (pre-RC), followed by the activation of individual origins of DNA replication by Cdc7/Dbf4 kinase....

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Vydáno v:Cell Cycle
Hlavní autoři: Knockleby, James, Kim, Byung Ju, Mehta, Avani, Lee, Hoyun
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934051/
https://ncbi.nlm.nih.gov/pubmed/27105124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1176658
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