Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint

Claspin is a critical mediator protein in the DNA replication checkpoint, responsible for ATR-dependent activation of the effector kinase Chk1. Cdc7, an essential kinase required for the initiation of DNA replication, can also interact with and phosphorylate Claspin. In this study we use small-molec...

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Autori principali: Rainey, Michael D., Harhen, Brendan, Wang, Guan-Nan, Murphy, Paul V., Santocanale, Corrado
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680535/
https://ncbi.nlm.nih.gov/pubmed/23598722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24675
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