Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

Claspin transmits replication stress signal from ATR to Chk1 effector kinase as a mediator. It also plays a role in efficient replication fork progression during normal growth. Here we have generated conditional knockout of Claspin and show that Claspin knockout mice are dead by E12.5 and Claspin kn...

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Vydáno v:Nat Commun
Hlavní autoři: Yang, Chi-Chun, Suzuki, Masahiro, Yamakawa, Shiori, Uno, Syuzi, Ishii, Ai, Yamazaki, Satoshi, Fukatsu, Rino, Fujisawa, Ryo, Sakimura, Kenji, Tsurimoto, Toshiki, Masai, Hisao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945878/
https://ncbi.nlm.nih.gov/pubmed/27401717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12135
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