Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

Claspin transmits replication stress signal from ATR to Chk1 effector kinase as a mediator. It also plays a role in efficient replication fork progression during normal growth. Here we have generated conditional knockout of Claspin and show that Claspin knockout mice are dead by E12.5 and Claspin kn...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Commun
मुख्य लेखकों: Yang, Chi-Chun, Suzuki, Masahiro, Yamakawa, Shiori, Uno, Syuzi, Ishii, Ai, Yamazaki, Satoshi, Fukatsu, Rino, Fujisawa, Ryo, Sakimura, Kenji, Tsurimoto, Toshiki, Masai, Hisao
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2016
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945878/
https://ncbi.nlm.nih.gov/pubmed/27401717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12135
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