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Cdc7 activates replication checkpoint by phosphorylating the Chk1-binding domain of Claspin in human cells
Replication checkpoint is essential for maintaining genome integrity in response to various replication stresses as well as during the normal growth. The evolutionally conserved ATR-Claspin-Chk1 pathway is induced during replication checkpoint activation. Cdc7 kinase, required for initiation of DNA...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6996922/ https://ncbi.nlm.nih.gov/pubmed/31889509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50796 |
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