Roles of Replication Fork-interacting and Chk1-activating Domains from Claspin in a DNA Replication Checkpoint Response

Claspin is essential for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing incompletely replicated DNA. Claspin associates with replication forks upon origin unwinding. We show that Claspin contains a replication fork-interacting domain (RFID, residues 265–605) that associates...

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Main Authors: Lee, Joon, Gold, Daniel A., Shevchenko, Anna, Shevchenko, Andrej, Dunphy, William G.
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2005
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1266425/
https://ncbi.nlm.nih.gov/pubmed/16148040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-07-0671
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