Mechanism of Cancer Cell Death Induced by Depletion of an Essential Replication Regulator

BACKGROUND: Depletion of replication factors often causes cell death in cancer cells. Depletion of Cdc7, a kinase essential for initiation of DNA replication, induces cancer cell death regardless of its p53 status, but the precise pathways of cell death induction have not been characterized. METHODO...

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Detalhes bibliográficos
Main Authors: Ito, Sayuri, Ishii, Ai, Kakusho, Naoko, Taniyama, Chika, Yamazaki, Satoshi, Fukatsu, Rino, Sakaue-Sawano, Asako, Miyawaki, Atsushi, Masai, Hisao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344859/
https://ncbi.nlm.nih.gov/pubmed/22574151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036372
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