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Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint
Claspin is a critical mediator protein in the DNA replication checkpoint, responsible for ATR-dependent activation of the effector kinase Chk1. Cdc7, an essential kinase required for the initiation of DNA replication, can also interact with and phosphorylate Claspin. In this study we use small-molec...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3680535/ https://ncbi.nlm.nih.gov/pubmed/23598722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24675 |
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