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SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication

Maintenance of genome stability requires that DNA is replicated precisely once per cell cycle. This is believed to be achieved by limiting replication origin licensing and thereby restricting the firing of each replication origin to once per cell cycle. CDC6 is essential for eukaryotic replication o...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Walter, David, Hoffmann, Saskia, Komseli, Eirini-Stavroula, Rappsilber, Juri, Gorgoulis, Vassilis, Sørensen, Claus Storgaard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738361/
https://ncbi.nlm.nih.gov/pubmed/26818844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10530
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