Upregulation of CD4 Expression during MHC-II Specific Positive Selection is Essential for Error-free Lineage Choice

The lineage fate of developing thymocytes is determined by the persistence or cessation of TCR signaling during positive selection, with persistent TCR signaling required for CD4 lineage choice. We now report that transcriptional upregulation of CD4 expression is essential for error-free lineage cho...

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Main Authors: Sarafova, Sophia D., Van Laethem, Francois, Adoro, Stanley, Guinter, Terry, Sharrow, Susan O., Feigenbaum, Lionel, Singer, Alfred
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758695/
https://ncbi.nlm.nih.gov/pubmed/19747858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.07.006
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