Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells

CTLA-4 proteins contribute to the suppressor function of regulatory T cells (Tregs), but the mechanism by which they do so remains incompletely understood. In the present study, we assessed CTLA-4 protein function in both Tregs and conventional (Tconv) CD4(+) T cells. We report that CTLA-4 proteins...

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Detalhes bibliográficos
Main Authors: Tai, Xuguang, Van Laethem, François, Pobezinsky, Leonid, Guinter, Terry, Sharrow, Susan O., Adams, Anthony, Granger, Larry, Kruhlak, Michael, Lindsten, Tullia, Thompson, Craig B., Feigenbaum, Lionel, Singer, Alfred
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369608/
https://ncbi.nlm.nih.gov/pubmed/22403258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-388918
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