IL-7 signaling must be intermittent, not continuous, during CD8 T cell homeostasis to promote cell survival instead of cell death

Maintenance of naive CD8 T cells is necessary for lifelong immunocompetence but for unknown reasons requires both interleukin-7 (IL-7) and T cell receptor (TCR) signaling. We now report that naive CD8 T cells require IL-7 signaling to be intermittent, not continuous, because prolonged IL-7 signaling...

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Detalhes bibliográficos
Main Authors: Kimura, Motoko Y., Pobezinsky, Leonid A., Guinter, Terry, Thomas, Julien, Adams, Anthony, Park, Jung-Hyun, Tai, Xuguang, Singer, Alfred
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552087/
https://ncbi.nlm.nih.gov/pubmed/23242416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2494
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