Foxp3 transcription factor is pro-apoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals

Immune tolerance requires regulatory T (Treg) cells to prevent autoimmune disease, with the transcription factor Foxp3 functioning as the critical regulator of Treg cell development and function. We report here that Foxp3 was lethal to developing Treg cells in the thymus because it induced a unique...

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Detalhes bibliográficos
Main Authors: Tai, Xuguang, Erman, Batu, Alag, Amala, Mu, Jie, Kimura, Motoko, Katz, Gil, Guinter, Terry, McCaughtry, Tom, Etzensperger, Ruth, Feigenbaum, Lionel, Singer, Dinah S., Singer, Alfred
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700677/
https://ncbi.nlm.nih.gov/pubmed/23746651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.02.022
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