Let-7 miRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function

Lethal-7 (let-7) microRNAs are the most abundant in the genome but their role in developing thymocytes is unclear. We now report that let-7 miRNAs target Zbtb16 mRNA, which encodes the lineage-specific transcription factor PLZF, to post-transcriptionally regulate PLZF expression and NKT cell effecto...

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Publicat a:Nat Immunol
Autors principals: Pobezinsky, Leonid A., Etzensperger, Ruth, Jeurling, Susanna, Alag, Amala, Kadakia, Tejas, McCaughtry, Tom M., Kimura, Motoko Y., Sharrow, Susan O., Guinter, Terry I., Feigenbaum, Lionel, Singer, Alfred
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406853/
https://ncbi.nlm.nih.gov/pubmed/25848867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3146
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