Identification of lineage-specifying cytokines that signal all CD8-cytotoxic lineage fate decisions in the thymus

T cell antigen receptor (TCR) signaling in the thymus initiates positive selection but CD8 lineage fate is thought to be induced by cytokines after TCR signaling has ceased, although this remains controversial and unproven. We now identify four non-common gamma chain (γc) receptor-signaling cytokine...

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Vydáno v:Nat Immunol
Hlavní autoři: Etzensperger, Ruth, Kadakia, Tejas, Tai, Xuguang, Alag, Amala, Guinter, Terry I., Egawa, Takeshi, Erman, Batu, Singer, Alfred
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659273/
https://ncbi.nlm.nih.gov/pubmed/28945245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3847
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