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Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors
Major histocompatibility complex class I (MHC I) positive selection of CD8(+) T cells in the thymus requires that T cell antigen receptor (TCR) signaling end in time for cytokines to induce Runx3d, the CD8-lineage transcription factor. We examined the time required for these events and found that th...
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| Publicado en: | Nat Immunol |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6691722/ https://ncbi.nlm.nih.gov/pubmed/27668801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3560 |
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