CD69 prevents PLZF(hi) innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation

While CD69 may regulate thymocyte egress by inhibiting S1P(1) expression, CD69 expression is not thought to be required for normal thymocyte development. Here we show that CD69 is in fact specifically required for the differentiation of mature NKT2 cells, which do not themselves express CD69. Mechan...

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Udgivet i:Nat Commun
Main Authors: Kimura, Motoko Y., Igi, Akemi, Hayashizaki, Koji, Mita, Yukiyoshi, Shinzawa, Miho, Kadakia, Tejas, Endo, Yukihiro, Ogawa, Satomi, Yagi, Ryoji, Motohashi, Shinichiro, Singer, Alfred, Nakayama, Toshinori
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138739/
https://ncbi.nlm.nih.gov/pubmed/30218105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06283-1
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