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Induction of autoimmune disease in CTLA-4(−/−) mice depends on a specific CD28 motif that is required for in vivo costimulation
CTLA-4-deficient mice develop a lethal autoimmune lymphoproliferative disorder that is strictly dependent on in vivo CD28 costimulation. Nevertheless, it is not known whether there is a specific site on the CD28 molecule that is required for induction of autoimmunity. Using CTLA-4-deficient mice exp...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1949493/ https://ncbi.nlm.nih.gov/pubmed/17702861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706509104 |
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