T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1

T cell receptor (TCR)–mediated inhibition of interleukin-7 (IL-7) signaling is important for lineage fate determination in the thymus and for T cell survival in the periphery because uninterrupted IL-7 signaling results in T cell death. The initial event in IL-7 signaling is the transactivation of J...

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Bibliografiska uppgifter
I publikationen:Sci Signal
Huvudupphovsmän: Katz, Gil, Pobezinsky, Leonid A., Jeurling, Susanna, Shinzawa, Miho, Van Laethem, Francois, Singer, Alfred
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679598/
https://ncbi.nlm.nih.gov/pubmed/25161318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005221
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