Progress toward allosteric ligands of metabotropic glutamate 7 (mGlu7) receptor: 2008–present

Por Vázquez-Villa, Henar, Trabanco, Andrés A.
Publicado no Medchemcomm (2018)

Identification of Allosteric Modulators of Metabotropic Glutamate 7 Receptor Using Proteochemometric Modeling

Por Tresadern, Gary, Trabanco, Andres A., Pérez-Benito, Laura, Overington, John P., van Vlijmen, Herman W. T., van Westen, Gerard J. P.
Publicado no J Chem Inf Model (2017)

Hydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation

Por Hell, Sandrine M., Meyer, Claudio F., Misale, Antonio, Sap, Jeroen B. I., Christensen, Kirsten E., Willis, Michael C., Trabanco, Andrés A., Gouverneur, Véronique
Publicado no Angew Chem Int Ed Engl (2020)

Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor

Por Lavreysen, Hilde, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Langlois, Xavier, Mackie, Claire, Pype, Stefan, Lütjens, Robert, Le Poul, Emmanuel, Trabanco, Andrés A, Nuñez, José María Cid
Publicado no Pharmacol Res Perspect (2015)

Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors

Por Rombouts, Frederik J. R., Tresadern, Gary, Buijnsters, Peter, Langlois, Xavier, Tovar, Fulgencio, Steinbrecher, Thomas B., Vanhoof, Greet, Somers, Marijke, Andrés, José-Ignacio, Trabanco, Andrés A.
Publicado no ACS Med Chem Lett (2015)

Spiro-oxindole Piperidines and 3-(Azetidin-3-yl)-1H-benzimidazol-2-ones as mGlu(2) Receptor PAMs

Por de Lucas, Ana Isabel, Vega, Juan Antonio, Matesanz, Encarnación, Linares, María Lourdes, García Molina, Aránzazu, Tresadern, Gary, Lavreysen, Hilde, Trabanco, Andrés A., Cid, José María
Publicado no ACS Med Chem Lett (2019)

Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ‐46281222

Por Doornbos, Maarten L J, Pérez‐Benito, Laura, Tresadern, Gary, Mulder‐Krieger, Thea, Biesmans, Ilse, Trabanco, Andrés A, Cid, Jose María, Lavreysen, Hilde, IJzerman, Adriaan P, Heitman, Laura H
Publicado no Br J Pharmacol (2016)

Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement

Por Buijnsters, Peter, De Angelis, Meri, Langlois, Xavier, Rombouts, Frederik J. R., Sanderson, Wendy, Tresadern, Gary, Ritchie, Alison, Trabanco, Andrés A., VanHoof, Greet, Roosbroeck, Yves Van, Andrés, José-Ignacio
Publicado em 2014

Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization

Por Doornbos, Maarten L. J., Wang, Xuesong, Vermond, Sophie C., Peeters, Luc, Pérez-Benito, Laura, Trabanco, Andrés A., Lavreysen, Hilde, Cid, José María, Heitman, Laura H., Tresadern, Gary, IJzerman, Adriaan P.
Publicado no J Med Chem (2018)

Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery

Por Sap, Jeroen B. I., Straathof, Natan J. W., Knauber, Thomas, Meyer, Claudio F., Médebielle, Maurice, Buglioni, Laura, Genicot, Christophe, Trabanco, Andrés A., Noël, Timothy, am Ende, Christopher W., Gouverneur, Véronique
Publicado no J Am Chem Soc (2020)

Hydrogen Bonding Phase-Transfer Catalysis with Ionic Reactants: Enantioselective Synthesis of γ-Fluoroamines

Por Roagna, Giulia, Ascough, David M. H., Ibba, Francesco, Vicini, Anna Chiara, Fontana, Alberto, Christensen, Kirsten E., Peschiulli, Aldo, Oehlrich, Daniel, Misale, Antonio, Trabanco, Andrés A., Paton, Robert S., Pupo, Gabriele, Gouverneur, Véronique
Publicado no J Am Chem Soc (2020)

Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches

Por Rombouts, Frederik J. R., Alexander, Richard, Cleiren, Erna, De Groot, Alex, Carpentier, Michel, Dijkmans, Joyce, Fierens, Katleen, Masure, Stefan, Moechars, Diederik, Palomino-Schätzlein, Martina, Pineda-Lucena, Antonio, Trabanco, Andrés A., Van Glabbeek, Daan, Vos, Ann, Tresadern, Gary
Publicado no ACS Omega (2017)

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis

Por Miles, Luke A., Hermans, Stefan J., Crespi, Gabriela A.N., Gooi, Jonathan H., Doughty, Larissa, Nero, Tracy L., Markulić, Jasmina, Ebneth, Andreas, Wroblowski, Berthold, Oehlrich, Daniel, Trabanco, Andrés A., Rives, Marie-Laure, Royaux, Ines, Hancock, Nancy C., Parker, Michael W.
Publicado no iScience (2019)

Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads

Por Oehlrich, Daniel, Peschiulli, Aldo, Tresadern, Gary, Van Gool, Michiel, Vega, Juan Antonio, De Lucas, Ana Isabel, Alonso de Diego, Sergio A., Prokopcova, Hana, Austin, Nigel, Van Brandt, Sven, Surkyn, Michel, De Cleyn, Michel, Vos, Ann, Rombouts, Frederik J. R., Macdonald, Gregor, Moechars, Dieder, Gijsen, Harrie J. M., Trabanco, Andrés A.
Publicado no ACS Med Chem Lett (2019)

Dihydrothiazolopyridone Derivatives as a Novel Family of Positive Allosteric Modulators of the Metabotropic Glutamate 5 (mGlu(5)) Receptor

Por Bartolomé-Nebreda, José Manuel, Conde-Ceide, Susana, Delgado, Francisca, Iturrino, Laura, Pastor, Joaquín, Pena, Miguel Ángel, Trabanco, Andrés A., Tresadern, Gary, Wassvik, Carola M., Stauffer, Shaun R., Jadhav, Satyawan, Gogi, Kiran, Vinson, Paige N., Noetzel, Meredith J., Days, Emily, Weaver, C. David, Lindsley, Craig W., Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Rombouts, Frederik, Lavreysen, Hilde, Macdonald, Gregor J., Mackie, Claire, Steckler, Thomas
Publicado em 2013

Discovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

Por Cid, Jose María, Duvey, Guillaume, Cluzeau, Philippe, Nhem, Vanthea, Macary, Karim, Raux, Alexandre, Poirier, Nicolas, Muller, Jessica, Boléa, Christelle, Finn, Terry, Poli, Sonia, Epping-Jordan, Mark, Chamelot, Emilie, Derouet, Francis, Girard, Francoise, Macdonald, Gregor J., Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Lavreysen, Hilde, Linares, María Lourdes, Oehlrich, Daniel, Oyarzábal, Julen, Tresadern, Gary, Trabanco, Andrés A., Andrés, Jose Ignacio, Le Poul, Emmanuel, Imogai, Hassan, Lutjens, Robert, Rocher, Jean-Philippe
Publicado em 2010