Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis

Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection. Thus, CD33 inhibition might be an effective therapy against disease progression. Progress toward discovery of sele...

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Bibliographic Details
Published in:iScience
Main Authors: Miles, Luke A., Hermans, Stefan J., Crespi, Gabriela A.N., Gooi, Jonathan H., Doughty, Larissa, Nero, Tracy L., Markulić, Jasmina, Ebneth, Andreas, Wroblowski, Berthold, Oehlrich, Daniel, Trabanco, Andrés A., Rives, Marie-Laure, Royaux, Ines, Hancock, Nancy C., Parker, Michael W.
Format: Artigo
Language:Inglês
Published: Elsevier 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6669322/
https://ncbi.nlm.nih.gov/pubmed/31369984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.07.023
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