Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ‐46281222

BACKGROUND AND PURPOSE: Allosteric modulation of the mGlu(2) receptor is a potential strategy for treatment of various neurological and psychiatric disorders. Here, we describe the in vitro characterization of the mGlu(2) positive allosteric modulator (PAM) JNJ‐46281222 and its radiolabelled counter...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Doornbos, Maarten L J, Pérez‐Benito, Laura, Tresadern, Gary, Mulder‐Krieger, Thea, Biesmans, Ilse, Trabanco, Andrés A, Cid, Jose María, Lavreysen, Hilde, IJzerman, Adriaan P, Heitman, Laura H
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728424/
https://ncbi.nlm.nih.gov/pubmed/26589404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13390
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