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Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2
BACKGROUND AND PURPOSE: The activation of the metabotropic glutamate receptor 2 (mGlu(2)) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can provide a fine-tune...
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| Pubblicato in: | Br J Pharmacol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BlackWell Publishing Ltd
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4403101/ https://ncbi.nlm.nih.gov/pubmed/25571949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13065 |
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