Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery

[Image: see text] Molecular editing such as insertion, deletion, and single atom exchange in highly functionalized compounds is an aspirational goal for all chemists. Here, we disclose a photoredox protocol for the replacement of a single fluorine atom with hydrogen in electron-deficient trifluorome...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Sap, Jeroen B. I., Straathof, Natan J. W., Knauber, Thomas, Meyer, Claudio F., Médebielle, Maurice, Buglioni, Laura, Genicot, Christophe, Trabanco, Andrés A., Noël, Timothy, am Ende, Christopher W., Gouverneur, Véronique
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7304874/
https://ncbi.nlm.nih.gov/pubmed/32379965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c03881
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