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Synthesis of (18)F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [(18)F]fluoride
Herein, we report the radiosynthesis of (18)F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [(18)F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated (18)F-fluo...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6429591/ https://ncbi.nlm.nih.gov/pubmed/30996907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05096a |
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