Synthesis of (18)F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [(18)F]fluoride

Herein, we report the radiosynthesis of (18)F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [(18)F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated (18)F-fluo...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Chem Sci
Autors principals: Sap, Jeroen B. I., Wilson, Thomas C., Kee, Choon Wee, Straathof, Natan J. W., Ende, Christopher W. am, Mukherjee, Paramita, Zhang, Lei, Genicot, Christophe, Gouverneur, Véronique
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2019
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429591/
https://ncbi.nlm.nih.gov/pubmed/30996907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05096a
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars