Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C–O Cross-Coupling

[Image: see text] Herein, we report a highly effective protocol for the cross-coupling of (hetero)aryl bromides with fluorinated alcohols using the commercially available precatalyst (t)BuBrettPhos Pd G3 and Cs(2)CO(3) in toluene. This Pd-catalyzed coupling features a short reaction time, excellent...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Szpera, Robert, Isenegger, Patrick G., Ghosez, Maxime, Straathof, Natan J. W., Cookson, Rosa, Blakemore, David C., Richardson, Paul, Gouverneur, Véronique
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458480/
https://ncbi.nlm.nih.gov/pubmed/32806200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c02347
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