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Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides

Pyridine rings are ubiquitous in drug molecules; however, the pre-eminent reaction used to form carbon–carbon bonds in the pharmaceutical industry, the Suzuki–Miyaura cross-coupling reaction, often fails when applied to these structures. This phenomenon is most pronounced in 2-substituted pyridines,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Chem Sci
Hauptverfasser: Markovic, Tim, Rocke, Benjamin N., Blakemore, David C., Mascitti, Vincent, Willis, Michael C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590096/
https://ncbi.nlm.nih.gov/pubmed/28936330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc00675f
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